Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance
نویسندگان
چکیده
منابع مشابه
Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance
Aminoglycosides are a class of antibiotics with a broad spectrum of antimicrobial activity. Unfortunately, resistance in clinical isolates is pervasive, rendering many aminoglycosides ineffective. The most widely disseminated means of resistance to this class of antibiotics is inactivation of the drug by aminoglycoside-modifying enzymes (AMEs). There are two principal strategies to overcoming t...
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The newly introduced semisynthetic aminoglycoside antibiotics, i.e., 3',4'-dideoxykanamycin B (DKB), 6'-N-methyl DKB (6'-Me-DKB) and amikacin (AK) have been found to be effective against gram-negative pathogens including Pseudomonas aeruginosa, which are resistant to the known aminoglycoside antibiotics. We have demonstrated in our stock cultures two types of P. aeruginosa strains resistant to ...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2013
ISSN: 2235-2988
DOI: 10.3389/fcimb.2013.00022